Vol. 11, Issue 4 (2022)

Author(s):
Sunil Hajare, Ranjit Suresh Ingole, Mahesh Kumar Vitthal Ingawale, Vivek Borekar, David Kumar and Bhaskar Ganguly

Abstract:
Maintaining fertility is essential for successful dairy enterprise. Fertility is widely challenged by a number of problems like anovulation, delayed ovulation, silent estrus, and anestrus. AV/OIP/22 (M/s Ayurvet Limited, India) is a polyherbal estrus inducer that helps to maintain and restore better reproductive efficiency. A study was conducted to assess the acute oral toxicity of AV/OIP/22 according to OECD 423 guidelines. Nine adult female Swiss albino mice, weighing 25-28 g, were used for the study. Following the oral administration of AV/OIP/22, the animals were observed for the manifestation of toxic effects and mortality. Toxicity was evaluated on the basis of changes in weight, signs of toxicity, histology of important organs (heart, liver, kidney, and lungs), and blood biochemical parameters (AST, ALT, ALP and creatinine). No toxic effects or mortalities were noticed until day 14 and AV/OIP/22 was found safe for oral consumption.