Vol. 6, Issue 10 (2017)

Author(s):
Pawan Jalwal and Anil Middha

Abstract:
Famotidine is histamine H2 receptor antagonist in treating gastric ulcer, duodenal ulcer, Zollinger Ellison syndrome, gastroesophegal reflux disease and erosive esophagitis. It inhibits acid production by reversibly competing with histamine for binding to H2 receptors on the basolateral membrane of parietal cells. It competitively inhibits histamine action at all H2 receptors but their main clinical use is as inhibition of gastric acid secretion. It inhibited histamine stimulation and gastrin stimulated acid secretion. It decreases both basal and food stimulated acid secretion by 90% or more, but promote healing of duodenal ulcer. The swelling of the polymers used (HPMC K15M, Ethyl cellulose, Xanthan Gum) were determined by water uptake of the tablet. The percent swelling of the tablet was determined for 12 h at different time intervals. In present work an attempt was made to prepare the Floating Tablet of Famotidine using different polymers by wet granulation and direct compression method with Lactose, DCP and MCC as diluents, citric acid and Sodium bicarbonate as gas generating agent.