Vol. 11, Issue 7 (2022)

Author(s):
BH Choudhury, S Islam, Om Singh and P Mohan

Abstract:
The crude and purified extracts of Scorporia dulcis were used to study the hepatoprotective/hepatocurative activity in albino rats. Two doses of extracts viz. 100mg, 300mg of crude and 10mg, 30mg of purified extracts per kg body weight were given orally to albino rats for 7 days. On the 3rd and 6th days the animal, received CCl₄ @3ml/kg body weight and olive oil subcutaneously (50:50). Control group of animals were also maintained. On the 8th day of the experiment, blood samples were collected by direct puncture of the heart and the serum was extracted from the samples. The animals were then sacrificed by chloroform and the tissue samples (liver) were used for hepatoprotective studies. To assess the extent of hepatic damage and to monitor the degree of hepatoprotection of the extracts serum alkaline phosphatase, serum-γ-glutamyl transferase, serum glutamate pyruvate transaminase, total bilirubins were assayed. It was observed that the animals fed with the crude and purified extracts exhibited statistically highly significant hepatoprotective action in comparison to animals treated with only CCl₄ which resulted hepatic disorder.