Vol. 6, Issue 11 (2017)

Author(s):
Sumira Aziz and Mohd Ashraf Ganaie

Abstract:
The liver is an organ of prime importance and plays a significant role not only in metabolism and detoxification of exogenous toxins and therapeutic agents, but also in the bio-regulation of blood coagulation and immuno-modulation. The investigation of the preliminary phyto chemical qualitative examination of ethanol and aqueous extracts of Eclipta alba L. shows presence of different haemotological parameters Haematological parameters namely RBCs, HB,WBC, PCV, and differential counts were monitored in this study because of their diagnostic significance and role in providing information concerning haematological changes caused by acetaminophen (paracetamol) induced toxicity. The effect of Eclipta alba on haematological parameters in control and acetaminophen induced hepatotoxic rats. The PVC was significantly reduced (P<0.05) only in hepatotoxic group treated with Eclipta alba extract while neutrophils were also reduced in hepatotoxic control. A single oral dose of the acetaminophen @ 750mg/kg body weight significantly (p<0.01), reduced Hb and increased MCV and MCH of the acetaminophen group as compared to control group. Simultaneous treatment with Eclipta alba extracts significantly increased the levels of Hb and decreased the levels of MCV and MCH. Agents capable of enhancing survival in the Acetaminophen inducing haemopoietic syndrome have typically been associated with accelerated haemopoietic regeneration.