Vol. 6, Issue 11 (2017)

Author(s):
Pragati Patel, Aditya Mishra, Amir Amin Sheikh, Rakshanda Bhagat, Priya Waliya, Sheikh Tajamul Islam, Gowher Gull Sheikh and Shabir Mir

Abstract:
Adrenomedullin is a novel peptide hormone, abundantly found in the adrenal medulla, this accounts the name adrenomedullin. This peptide is a member of the calcitonin gene-related peptide family that include calcitonin, amyline and intermedin. Its production is up-regulated by several factors such as oxidative stress, pro-inflammatory cytokines, angiotensin II, hypoxia, hyperglycemia, natriuretic peptide and aldosterone. Also the potent effects of AM on cell migration, growth, and apoptosis (programmed cell death) have led to the hypothesis that AM may play a key role in tumor growth and metastasis. AM is a multifunctional peptide hormone that can exert many important and interrelated biological functions under both normal and disease conditions like atherosclerosis, septic shock, cardiac failure, renal failure, bronchial asthma, diabetes and neoplasm.