Vol. 11, Issue 9 (2022)

Author(s):
Syed Kashif Mohiuddin, Dr. Pittu Vishnu Priya, Syed Mohammed Wajhi Ul Hasan and Abdul Raziq Musharaf

Abstract:
The drug interactions of Warfarin and Rifampicin are commonly seen but not well known Rifampicin has been reported to increase the dose of Warfarin, hence there is strict need to maintain the dose of Warfarin that is 20 Mg/day to get the desired therapeutic effect of warfarin (anticoagulant) If the Rifampicin is withdrawn from the treatment chart, it will reduce the Warfarin requirement by 50% Rifampicin has the potential to induce the hepatic enzyme cytochrome P450 (CYP) and Warfarin is metabolised by enzyme cytochrome P-450 (CYP) hence increases the risk of drug-drug interactions. When these both drugs ie Rifampicin and Warfarin are co-administered then the therapy shall be continuously Monitored by (INR) International Normalized Ratio. Significant increase in warfarin doses are more likely seen. This case report focuses on termination of the co-administration of Rifampicin and Warfarin.