Vol. 11, Issue 10 (2022)

Author(s):
Vijay Kumar Juyal, Om Prakash, Ajay Kumar Tiwari and Viveka Nand

Abstract:
A Fe (III) complex of N, O donor bidentate α-aminophosphonates was synthesized in a 1:2 (ligand: metal) molar ratio and characterized by different analytical and physicochemical methods including FTIR, molar conductance, AAS, elemental analysis and NMR (¹H and ¹³C). The prepared ligand and metal complex were screened for antibacterial activity against two gram-positive (Staphylococcus aureus and Bacillus subtilis) and two gram-negative (Escherichia coli and Salmonella typhi) bacteria by disk-diffusion methods using various concentrations of compounds (250, 500, 750, 1000 ppm). Amikacin was used as standard and a comparison of the inhibition zone indicates that the Fe (III) complex showed more antibacterial activity than the ligand. A molecular docking study was also carried out for the prepared ligand and complex against S aureus Tyrosyl-tRNA synthetase protein (PDB ID-1JIL) using AutoDock 4.2 software in which both ligand and complex showed good interaction.