Vol. 7, Issue 1 (2018)

Author(s):
Pooja Verma

Abstract:
Diabetic Neuropathy is the most prevalent and costly complication of hyperglycemia that is affecting half of the patient worldwide and its incidence rate has increased upto several folds. It includes impairment of pain signalling pathways. The aim of the investigation was to determine the effect of alpha-lipoic acid in Streptozotocin induced diabetic neuropathic pain in rats by oral route, intraperitoneal route, Preparation of nano-emulsion of alpha lipoic acid and evaluate its effect by oral and intraperitoneal route as well as to determine effect of alpha-lipoic acid on diabetes itself. Alpha-lipoic acid and its Nano-formulation was orally and intraperitoneal administered to STZ induced diabetic rats for 3 weeks. Tail flick latency and tail immersion test were done to determine thermal hyperalgesia, Randall-selitto paw pressure test to determine mechanical hyperalgesia, von-frey hair to mechano-tactile allodynia and Hot plate for mechanical nociception at different time intervals i.e., 2nd and 3rd week.