Vol. 11, Issue 12 (2022)

Author(s):
Mishra A, Shahi A, Jawre S, Vaish R, Singh AP, Dubey A, Singh R, Das B, Dwivedi PK, Ramyavani KB and Shinde P

Abstract:
Rabbit models of ocular diseases are particularly useful since rabbits can be easily handled, while sharing more common anatomical and biochemical features with animals including longer life span and larger eye size. In the present study rabbit eye model was used to access the effect of corneal alkali burn. In all the eyes, approximately 5-6 mm in diameter, full thickness corneal defect was created by placing a filter paper soaked in 1N NaOH (pH 13±0.6) solution at axial cornea for 30 secs. The eyes were treated by giving conventional medicinal treatment of eye drop Moxifloxacin and Flurbiprofen for 07 days post alkali burn induction. Post induction of alkali burn there was significant increase in STT values from 6.3±0.49 to 9.00±1.00mm/min between day 03 and 30. Size of corneal alkali burn increased from 6.00± 0.00 to 7.50 ± 0.50 mm in all animals from day 03 to 30 along with marked retention of fluorescein dye indicative of corneal ulceration.