Vol. 7, Issue 3 (2018)

Author(s):
Bhuvaneshwari R Sharannavar and Anand P Gadad

Abstract:
The aim of the present study was to improve the solubility and dissolution of poorly water soluble drug Lovastatin (LVS). Solid dispersions were prepared by using PVPK30 and aerosil 200 by spray drying method, with different drug: polymer ratio (1:1, 1:2, 1:4 and 1:8). These formulations were charecterized by the saturation solublity, IR, DSC, PXRD and SEM. The aqueous solubility of LVS was favoured by the presence of polymer PVPK30. In contrast to the very slow dissolution rate of pure LVS, spray dried solid dispersions considerably improved the dissolution rate. This can be attributed to the increased wettability and dispersibility of LVS in polymeric matrix of PVPK30 as well as decreased crystallinity and increase in amorphicity which is confirmed by PXRD, DSC and SEM. IR studies also revealed that there is hydrogen bonding formation between drug LVS and PVPK30. The formulation SD4 showed highest solubility and dissolution rate. Stability study confirmed that there is no recrystallinity of drug over storage for specific period.