Vol. 7, Issue 4 (2018)

Materials and methods: 64 pregnant women with chronic arterial hypertension on 30-36 weeks of gestation were examined. For the clinical assessment of the pregnant women state there were considered: monitoring of the blood pressure, echocardiography, blood and urine analyses, proteinuria assessment. To evaluate the function of the endothelium, the modified D. Celermajer technique was used; to evaluate the functional state of the fetus cardiotocography (CTG) and the fetal biophysical profile (BPP) were used. Endothelin -1 concentration and the number of desquamated endotheliocytes in the blood serum were studied for the evaluation of biochemical markers of endothelial function.

Results of the study and their discussion: It was found that, in pregnant women with arterial hypertension during the initial stage there is a central and peripheral hemodynamics disorder, and its severity directly correlates with the severity of the endothelial dysfunction and an increased risk of gestational and perinatal complications.

Conclusions: Tight control of arterial hypertension with normalization of arterial pressure due to inclusion of nebivolol hydrochloride (highly selective beta-blocker with vasodilating properties) in the management program allows to prevent the progression of endothelial dysfunction and aggravation of hemocirculation disorders, including the mother-placenta-fetus system. This fact ultimately leads to normalization of Manning score (parameters of biophysical profile).