Vol. 7, Issue 4 (2018)

Author(s):
U Naseema, Ganne Venkata Sudhakar Rao, N Pazhanivel, V Pandiyan and P Sriram

Abstract:
The present study was aimed to evaluate the anticancer potential of piperine solid lipid nanoparticle against benzo(a)pyrene induced lung cancer by analysing the haematological changes in experimental mice. Benzo(a)pyrene was administered orally (50 mg/kg body weight) to induce lung cancer in Swiss albino mice. The levels of haemoglobin (Hb), packed cell volume (PCV), total erythrocyte count (TEC), lymphocytes and platelets (PLT) were lower while the levels of total leukocyte count (TLC) and neutrophils were higher in the mice administered with benzo(a)pyrene alone and in combination with piperine. Post-treatment with piperine solid lipid nanoparticles (100mg/kg body weight) significantly reversed all these changes. The results of this study indicated the potential benefits of piperine and its nanoparticle in cancer treatment in Swiss albino mice.