Vol. 12, Issue 3 (2023)

Author(s):
Ravikumar C, Jagadeesh S Sanganal, Shridhar NB, Sunilchandra U, Ramachandra SG and Shivashankar BP

Abstract:
The present study was conducted on Pharmacokinetics of Levofloxacin Through intravenous route of Administration in Dual Purpose Chicken by the LCMS/MS Analytical Technique. The experimental birds (n=10) were randomly allocated to receive single i.v dose of the levofloxacin drug. The levofloxacin drug was administered at a single dose rate 8 mg/kg bw through i.v administration, Following i.v administration, blood samples were collected at time 0 (before drug administration), 5, 10, 15, 30 and 45 min 1, 2, 3, 4, 6, 8, 12, 16 and 24 h. Plasma samples were separated soon after blood collection by centrifugation (3500 rpm for 10 min at 4 °C), stored at -20 °C. The samples were analysed by LC-MS/MS equipment using PK solver system. In the present study, there was an increase in the values of AUC, AUMC, C_max, C⁰_p, t_1/2 and MRT pharmacokinetic parameters after i.v administration compared to the previous studies in the dual purpose chicken. In conclusion good bioavailability, large volume of distribution, high C_max, C_p^o, AUC and pharmacokinetic–pharmacodynamic hybrid efficacy predictors for levofloxacin indicated that administration of levofloxacin at 8 mg/kg bw through i.v route may be highly efficacious against susceptible bacteria in dual purpose chicken.