Vol. 7, Issue 4 (2018)

Author(s):
TA-BI Irié Honoré, AKE Claude Bernard, Konkon N’Dri Gilles and N'Guessan Koffi

Abstract:
The decoction of Corchorus olitorius leaves is used by ivorian traditional healers for the treatment of inflammation. Regarding the decoction used, this study was carried out to evaluate the anti-inflammatory activity of the acqueous extracts from C. olitorius leaves. These extracts were tested according to the model of acute edema of rat paw induced by carrageenan 1%. The doses of drug orally administered to the animals were as follow: 1470, 2450, 7350 mg / kg. The results obtained with the aqueous extracts of C. olitorius leaves were firstly compared with those of physiological control (NaCl 0.9%) and secondly with those of the reference anti-inflammatory (diclofenac sodium 25 mg / kg). The different comparisons were set up at 1 h, 2 h, 3 h, 4 h, 5 h, 6 h, 12 h and 24 h after the injection of carrageenan to the rats. The parameter considered to appreciate the activity of each treatment was the percentage of increase in leg circumference (% AUG). The results exhibited significant difference (p<0.001) between the % AUG of treatments from extracts of C. olitorius for different doses and those of NaCl. For a dose of 7350 mg / kg administered orally, AUG percentages of plant treatment are statically the same with those of diclofenac 25 mg / kg. This study revealed that the aqueous extracts from C. olitorius leaves have anti-inflammatory properties. It could be considered as a scientific basis for the empirical use of C. olitorius leaves in the treatment of inflammation.