Vol. 12, Issue 3 (2023)

Author(s):
R Edith, S Meignanalakshmi, K Vijayarani and M Balagangatharathilagar

Abstract:
Gastrointestinal parasitism has been the major cause for economic loss in small ruminant production. Haemonchus contortus, the stomach worm of sheep and goats has been incriminated for severe economic loss due to anemia, deceased growth rate, infertility and death in severe infections. Anthelmintic drugs have been used with variable rate of success but the treatment failure occurred due to anthelmintic resistance. It is the need of the hour to search for an alternate, sustainable and economical stategy for the treatment and control of H. contortus. Varios plants have been screened for anthelmintic potential using in vitro and in vivo models. The oyster mushroom, Pleurotus ostreatus has been explored for its various bioactive compounds proven for antitumour, antioxiadant and immunomodulatory properties. The present study explored the in vitro anthelmintic potential of mushroom enzyme hydrolysates on the H. contortus larval development. The mushroom protein hydrolysates (MPH) were prepared from trypsin, papain and pepsin. The MPHs were used to evaluate their in vitro anthelmintic activity using larval development assay. The results revealed that papain mushroom protein hydrolysate showed 100 percent mortality of H. contortus larvae compared to pepsin and trypsin mushroom hydrolysates. It is concluded that the oyster mushroom can be the potential alternate to anthelmintic drugs for the control of H. contortus.