Vol. 12, Issue 4 (2023)

Author(s):
Analisha Debbarma, Indramani Nath, Sidhartha Sankar Behera, Smruti Ranjan Mishra, Susen Kumar Panda and Ritun Patra

Abstract:
The study was conducted on 18 Swiss albino mice to determine the potency of betadine and collagen granules in wound healing. Two groups were made, i.e., Group-I (treated with betadine ointment) and Group-II (treated with collagen granules), each group containing 9 mice. An intraperitoneal injection of a mixture of 12.5 mg/kg of xylazine hydrochloride and 80 mg/kg of ketamine hydrochloride was used to induce anaesthesia, and a wound was created with the help of a 5mm biopsy punch on the dorsal area. On average, 17.8 ± 0.43 days in Group-I and 17.5 ± 0.42 days in Group-II were required for complete healing. The wound contraction area was 5.03 ± 0.06 mm, 4.40 ± 0.09 mm, and 3.88 ± 0.05 mm in Group-I and 4.85 ± 0.06 mm, 3.98 ± 0.06 mm, and 2.93 ± 0.04 mm in Group-II, respectively, on the 3^rd, 7th, and 14^th days. And collagen granules supplement show a faster healing process than betadine-treated wounds.