Vol. 12, Issue 4 (2023)

Author(s):
Dr. Anish Kumar, Dr. TK Sarkar, Dr. PS Maurya, Dr. Vipul Thakur, Dr. MV Jithin, Dr. Jeny K John and Dr. Ramakant

Abstract:
A study was carried out to compare the therapeutic efficacy between doxycycline and minocycline on clinical cases of canine monocytic ehrlichiosis (CME). Six CME infected dogs were treated with Doxycycline and six with CME infected dogs were treated with minocycline for 21 days. On the basis of the clinical examinations and laboratory findings (positive for Ehrlichiosis), 12 animals were selected and randomly divided into Groups I (N=6) and II (N=6). To compare the hemato-biochemical status of CME cases, 6 apparently healthy dogs were selected. Group I was administered doxycycline at the dose rate of 10 mg/kg b.wt. P/O OD for 21 days and Group II were administered minocycline at the dose rate of 20 mg/kg b.wt P/O BID for 21 days. Both group I &II supportive treatment were administered with standard dose of pantoprazole and domperidone combination syrup, silymarin syrup and haematenic syrup orally. After treatment with doxycycline and minocycline the haemato-biochemical parameters come back towards normal level on day 21 post therapy. A group of dogs treated with minocycline showed better results on clinical and haemato-biochemical parameters compared to dogs treated with doxycycline. Minocycline could be used for the treatment of E. canis infected dogs instead doxycycline.