Vol. 12, Issue 4 (2023)

Author(s):
Shibanjan Paul Roy, Kamal Deka and Shyam Prakash Rai

Abstract:
The present invention is generally directed to matrix type transdermal patches for treating hypertension and Parkinson’s disease. The present invention comprises of rasagiline mesylate and prazosin hydrochloride prepared by using different ratios of Eudragit RL 400 and hydoxy propyl methyl cellulose. Effect of protease granuleson permeation of rasagiline and prazosin analyzed. The patch so formed is nonirritant to the skin and possess maximum permeability. The present invention also relates to the method of producing the same. The transdermal patch shows 50% and 80% drug release for rasagiline mesylate and prazosin hydrochloride respectively in 250 hours. In this research total works done under the guidance of Guide-Mr. Shibanjan Paul Roy. Mr. Kamal Deka and Mr. Shyam Prakash Rai performed for the practical works and others work and note the reading.