Vol. 12, Issue 4 (2023)

Author(s):
S Kannan, Lokesh Makam and SP Venkatesh Prasad

Abstract:
Various formulations were prepared and evaluated for sustained release of Z-9-tricosene in open fields. Of all the formulations evaluated pH stabilised Carbopol 940 gel exhibited reasonable slow and sustained release of Z-9-tricosene for a good period but with high daily release potential. Activated zeolites 4A sorbed with the stabilised Z-9-tricosene formulation, exhibited a quick release, also with high daily release potential. A novel approach was developed to combine the pH modulated Carbopol 940 gel with the zeolites 4A, both charged with Z-9-tricosene formulation entrapped into the aqueous gel of Carbopol 940 and porous channels of the aluminosilicates of zeolites 4A. This newly developed formulation is eco-friendly, safe, and biodegradable and demonstrated slow, sustained, and extended release with an average release of 65.28±0.08 mgs of Z-9-tricosene, effectively for 15days with 1gm of loading dose.