Vol. 7, Issue 4 (2018)

Author(s):
P Senthil Kumar, A Arivuchelvan, A Jagadeeswaran, N Punniamurthy, P Selvaraj, PN Richard Jagatheesan and P Mekala

Abstract:
Disposition of enrofloxacin was characterized following intravenous and drinking water route administration at a dose of 10mg/kg in emus birds. Blood samples were collected from jugular vein at assigned time intervals. The plasma concentration of enrofloxacin and its active metabolite ciprofloxacin were measured by HPLC. Plasma concentration-time data and relevant parameters were best described by non-compartmental analysis. Following i.v. administration, t_1/2β, AUC_0-∞, MRT, V_darea and CL_B was 4.364±0.179h, 20.085±3.493µg.h/mL, 5.105±0.216h, 3.921±1.005L/kg and 0.629±0.164 L/h.kg, respectively. After drinking water route administration, t_1/2β, AUC_0-∞, MRT, V_darea and CL_B was 4.066±0.295h, 14.807±1.766μg.h/mL, 6.942±0.572h, 3.130±0.264, 0.713±0.064L/h.kg, respectively. The mean absolute bioavailability for enrofloxacin was 73.723±8.792%, respectively. The ratio of AUC_0-tcipro/ AUC_0-tenro was 7.764% and 9.834%, respectively for i.v. and drinking water route administration of enrofloxacin. From the pharmacokinetic data and PK/PD indices, the recommended doses of enrofloxacin in emu birds were 10mg/kg body weight once daily for i.v. and drinking water route against organisms susceptible to 0.25mg/mL and 0.125mg/mL, respectively. There were no much differences between the pharmacokinetic parameters of i.v and drinking water route in emu birds. Hence, it can be concluded that drinking water route is suitable and practicable method for emus and it is also desirable method for mass medication.