Vol. 12, Issue 5 (2023)

Author(s):
Pooja P Bachapalle, Babasaheb C Ghumare, Vikas V Karande, Vitthal S Dhaygude, Prashant P Mhase, VR Patodakar and Namrata S Kathole

Abstract:
Cancer is a major cause of death worldwide, and angiogenesis is critical in cancer progression. The development of new blood vessels and the nutrition of tumor cells are heavily dependent on angiogenesis. Thus, angiogenesis is an important process that occurs both during health and disease. Carica papaya has been used in traditional medicine to treat many ailments like immunomodulation, anti-inflammatory analgesics etc. The present study was undertaken to evaluate the effect of the ethanolic extract of C. papaya on angiogenesis in a mouse model. The sponge implantation method investigated the antiangiogenic potential, wherein significant inhibition of blood vessel formation, hemoglobin concentration and VEGF concentration were recorded. Animals (30) were divided into five groups where group I was kept as untreated, group II was treated with SU5416 and group III was treated with ethanolic extract of C. papaya. The results were compared with positive control SU5416 and the untreated group. By using the Cyanmethemoglobin method the mean (±SE) hemoglobin concentrations (µg/mg weight of sponge) in group I to III of mice were 1.868 ±0.07, 0.391±0.03 and 1.069±0.09, respectively. The mean (±SE) VEGF concentration (pg/mg weight of sponge) in groups I to III of mice were 2.442±0.20, 0.481±0.06 and 1.607±0.13, respectively. The MVD (±SE) per field from processed sponges in groups I to III of mice were 12.4 ±2.1, 1.2 ±0.29 and 10.8 ±1.01, respectively. The results of the present study suggested that the ethanolic extract of Carica papaya leaves possesses antiangiogenic activity.