Vol. 12, Issue 5 (2023)

Author(s):
Pathade DS, Gangane GR, Moregaonkar SD, Rathod PR, Patil DP, Jadhav ND, Swami SB, Kachave PB, Bawanthade UB and Patil AA

Abstract:
The present experiment was undertaken to investigate the toxic pathological, haemato-biochemical evaluation of Hymenocallis littoralis (Beach spider lily) in Wistar rats and amelioration by leaves powder of Achyranthes aspera was assessed. Fifty Wistar rats were procured for the study. Animals were acclimatized for a period of seven days and then divided into five groups of 10 rats (5 male+ 5 female) each. The group-I served as healthy control and was given standard feed and water ad libitum. The rats in group II were received 20% aq. extract of Hymenocallis littoralis (1000mg/kg body weight of animal) by an oral gavage, group III was administered an extract of Hymenocallis littoralis+ powder of Achyranthes aspera through feed. Group IV rats were fed with 1% of Achyranthes aspera powder and group V was administered both plants for 28 days. The present investigation last for the period of 28 days excluding acclimatization period. The blood and serum samples were drawn from retro-orbital plexus on 0, 14^th day and 28th day from the rats in each group for the estimation of haemato-biochemical indices. There was significantly decreased in hematological parameters i.e., Hb, TEC counts whereas TLC were significantly increased. The biochemical parameters such as indicators of liver health (i.e., Mean of AST and ALT values) and indicators of the kidney (i.e., Mean Creatinine, Mean BUN) of rats of this group II were significantly increased. However, mean serum TP were significantly reduced in group II in comparison to other heathy control and plant control group rats. The feeding of Achyranthes aspera leaves powder against sub-acute Hymenocallis littoralis toxicity showed partial ameliorative effects on haemato-biochemical parameters.