Vol. 12, Issue 6 (2023)

Author(s):
Dr. Neetu Tripathi

Abstract:
1,4 Dihydropyridine is a very feasible heterocyclic ring with various substituents at different positions. Many drugs are known to have Dihydropyridine nucleus like Vasodialator, bronchiodialator, anti-atherosclerotic, antitumar, antidiabetic and hepatoprotective agents. Dihydropyridine is a multifunctional compound and a lead molecule in the area of drug discovery. They are known to have resistant reversal property and the most important biological activity associated with 1,4 Dihydropyridine are calcium channel blocker so they are used in treatment of cardiovascular diseases. Further such compounds are also known to have antimicrobial activities as antibacterial and antifungal agents. Therefore the studies was carried out to synthesize the substituted 1, 4- Dihydropyridine derivate and to see the effect of compound against gram positive and gram negative bacteria. Its antibacterial activity was investigated under present study.