Vol. 12, Issue 6 (2023)

Author(s):
Sonu S Nair, Abhishek, Sudhir Kumar Prajapati, Sanjana, Shubham Saini, Athira V, Prasad Thomas, Bablu Kumar, VK Chaturvedi, Shivaprakash M Rudramurthy and Gyan Dev Singh

Abstract:
Dermatophytosis is a common cause of cutaneous mycoses in animals and humans. The most commonly encountered dermatophytes are Microsporum, Trichophyton and Nannizia species. In the study, we evaluated the antifungal susceptibility of 10 T. mentagrophytes complex isolates, 8 Nannizzia isolates, 4 Arthroderma isolates, and 30 M. canis isolates against seven commercially available antifungal discs (HiMedia) including miconazole (30 μg) fluconazole (10 μg), nystatin (50 μg), ketoconazole (30 μg), itraconazole (30 μg), clotrimazole (10 μg) and amphotericin B (20 μg). Clotrimazole was found to have the highest mean diameter of the zone of inhibition in Microsporum, Trichophyton and Nannizzia isolates. The lowest zone of inhibition was exhibited by fluconazole in all the tested isolates. Even though disc diffusion assays are not commonly performed, they will provide preliminary information about the most useful antifungal agent before initiating the therapeutics.