Vol. 12, Issue 6 (2023)

Author(s):
Yogendra Singh, Anil Kumar Gangwar, Sangeeta Devi Khangembam, Prafull Kumar Singh, Vipin Kumar Yadav and Ravi Prakash Goyal

Abstract:
The objective of the present study was to test the efficacy of bladder decellularized urinary bladder, pericardium and diaphragm of caprine matrix graft as cell delivery vehicle and to evaluate the process of bladder regeneration in rabbits. Partial cystectomy was performed on 24 adult New Zealand white rabbits and the defect (1 cm × 1 cm) was repaired with autograft (n=6 group A) and 1% EDC cross-linked decellularized urinary bladder (n=6 group B), pericardium (n=6 group C) and diaphragm (n=6 group D) of caprine origin. The healing was evaluated on the basis of clinical and haematobiochemical observations. In none of the animals signs of graft rejection were observed. The clinical and haematobiochemical observationsdid not reveal any pathological changes. The values of the WBC count, Blood Urea Nitrogen and Creatinine were not changed significantly and found within normal limit.