Vol. 12, Issue 6 (2023)

Author(s):
Majid Shafi, Dr. Showkat Ahmad Shah, Showkeen Muzamil Bashir, Masood Saleem Mir, Shayaib Ahmad Kamil, Shabia Shabir, Akeel Bashir Sami Jan, Fozia Shah and Shahzada Mudasir

Abstract:
Metformin is an antidiabetic drug used to lower the blood sugar level in type 2 diabetic Patients. The chronic use of metformin for long duration may lead to nephropathy in humans and animals. This experimental study was conducted to assess the long term impact of Metformin on the structure and functionality of kidneys in rats. In this study, twenty adult male and female wistar rats were used for the investigation of Metformin induced sub-acute toxicity. The animals were randomly distributed into two groups and 10 animals are kept in each group. The first group served as the control and the second group received Metformin hydrochloride at a dose of 30 mg/kg body weight/day for a period of thirty consecutive days. All the animals were sacrificed at the end of study period in order to analyze the hematological, serological and the Nephropathological changes observed in the kidneys of rats. The results revealed that Metformin causes severe pathomorphological conditions in rats as evidenced by serum analysis and histopathology of kidneys.