Vol. 12, Issue 7 (2023)

Author(s):
Kaveri M Jambagi, Debabrata Mondal, Raguvaran R, Rajashekhar Kamalla, Ensha Lomiya MA and Dr. Med Ram Verma

Abstract:
Chronic kidney disease (CKD) in dogs is a progressive condition that affects the kidneys' ability to function properly over time. It is characterised by non-regenerative anaemia, hyperphosphatemia, hypertension and bone marrow abnormality. Multimodal approach is required to treat the patients with CKD in order to prevent the vicious cycle of CKD. This study aimed to assess the efficacy of encapsulated probiotic in canine kidney failure cases. Eighteen (18) dogs with CKD IRIS stage 2 and /or 3 were enrolled in this study and divided into different groups randomly to evaluate the effects of conventional treatment, probiotics, and encapsulated probiotics. Blood and serum samples were collected from the dogs for hematological and biochemical analysis. Urine analysis and ultrasonography were also performed. The results of the study showed that dogs with CKD had lower levels of hemoglobin and packed cell volume (PCV) compared to healthy dogs. However, on day 10 of the study, the group received encapsulated probiotics showed a significant (p<0.05) increase in PCV levels as compared to day 0, suggested potential improvement in anemia with probiotic supplementation. In terms of biochemical parameters, significant (p<0.05)improvements were observed in creatinine, blood urea nitrogen (BUN), and serum glutamic pyruvic transaminase (SGPT) levels in the group received encapsulated probiotics compared to the conventional therapy group and non-encapsulated probiotic group. The study suggests that the supplementation of encapsulated probiotics in dogs with CKD may have beneficial effects on kidney function.