Vol. 7, Issue 6 (2018)

Author(s):
J Talpade, K Shrman, RK Sharma, YP Sahni, RP Singh and S Soman

Abstract:
Enrofloxacin is a second generation fluoroquinolone, specially developed for therapeutic purpose in veterinary practice and extensively used in goats for therapeutic purposes. The present study was planned to study the pharmacokinetic of enrofloxacin after single dose intramuscular administration in 6 healthy Barbari goats. The study was conducted by following cross-over design. The enrofloxacin was injected @ 5mg/kg body weight through intramuscular route. After drug administration, blood sample were collected at different time intervals and the plasma concentration of enrofloxacin were measured by high performance liquid chromatography (HPLC) having PDA detector. The mean peak plasma drug concentration of 0.38±0.05 mg.ml^-1 was achieved at 1h, however, effective therapeutic concentration (0.1mg.ml^-1) was maintained up to 4h with mean concentration of 0.17±0.03 mg.ml^-1 at 4 h. The mean absorption half-life of (t_1/2ka) and elimination half-life (t_{1/2 b}) were calculated to be 0.25±0.05h, and 2.07±0.31h, respectively. The mean apparent volume of distribution (Vd_area), volume of distribution at steady state (Vd_ss) and mean residential time (MRT) was calculated to be 10851.49±1353.06ml.kg^-1, 12123.31±1196.69ml.kg^-1 and 3.35±0.40h, respectively.