Vol. 12, Issue 8 (2023)

Author(s):
Seema Agarwal and DK Agrawal

Abstract:
The chemical industry comprises the companies that produce industrial chemicals. Effluents from chemical industries are released abundantly into the environment many times without proper treatment. Limited investigations have been carried out on the impact of chemical industry effluents on the quality of fresh water as well as on health of animals and men. Therefore, present study was done to study the effect of chemical industry effluent on haematological parameters in mice. To study the effect of chemical industry effluent on haematological parameters, two-weeks-old 256 mice procured from Indian Veterinary Research Institute, Izatnagar, Bareilly were randomly divided into four equal groups of 64 mice each viz. control (group-I), R2B vaccine + effluent treated (group-2), effluent treated (group-3) and R2B vaccinated (group-4). The vaccine used was R2B strains given to group-2 and 4 @ 0.1 ml by intraperitoneal route. All the haematological parameters viz. Haemoglobin, Total Erythrocyte Count (TEC), Packed Cell Volume (PCV), Total Leukocyte Count (TLC), lymphocytes, neutrophils, monocytes, eosinophils and basophils count were performed on the day of blood collection at every 15 days interval upto 120 days of experimentation as per the standard method. In the present study, the haematological investigations revealed non significant decrease in haemoglobin, TEC and PCV values up to 75 days of observation in groups 2 and 3 mice in comparison to groups 1 and 4 mice. From 90 to 120 days of observation, a significant decrease in the values of haemoglobin, PCV and TEC was observed in groups 2 and 3 mice in comparison to groups 1 and 4 mice. The decrease in haemoglobin level, TEC and PCV may be because of effect of lead and heavy metals on the haemopoietic system. Heavy metals like lead and cadmium accumulate in erythrocytes and affect haeme synthesis by inhibiting the absorption of iron from the gut.