Vol. 12, Issue 8 (2023)

Author(s):
Miteshkumar N Hingu and Dr. Vimal M Ramani

Abstract:
Folic acid is a B9 vitamin, which requires in the human body to make new cells. So, everyone needs folic acid and particularly for the pregnant women to prevent major birth defects of her baby. The free folic acid and its bioavailability is affected by parameters like pH and bile in the gastrointestinal tract. The nanoencapsulation of such type of bioactive component can be used to protect it from adverse gastrointestinal environmental conditions as well as it improves the bioavailability, stability and controlled release at targeted site. So, in the present study, the nanoencapsulation of folic acid was carried out using electrospraying and the release profile of nanoencapsulated folic acid was studied. Release profile of nanoencapsulated folic acid was found better at 7 pH and 1.5% bile as compared to 4 pH and 0.5% bile, respectively. The highest release of nanoencapsulated folic acid i.e. 99.88 µg was observed when exposed to 7 pH up to 240 minutes. In case of bile exposure, the highest release of the nanoencapsulated folic acid i.e. 83.83 µg was observed at 1.5% bile up to 240 minutes. So, the maximum release of nanoencapsulated folic acid may help the consumers for better bioavailability.