Vol. 7, Issue 7 (2018)

Author(s):
Svitlana Heryak and Nataliia Petrenko

Abstract:
Objectives. To evaluate the efficacy of sublingual form of natural micronized progesterone and calcium channel blockers for treatment of threatened preterm labour in women that have had infections during pregnancy. Methods: A retrospective analysis of case histories of pregnant women with preterm labour in gestational age 22-36 weeks was performed. Nature of complaints, history, structural changes of the cervix, concentration of pro- and anti-inflammatory cytokines were determined. Results:Preterm labour occurred to employed women (79%), most of them (60%) are office workers with physical inactivity and computer. Preconditions for occurrence of preterm labour were complicated course of gestational process (36%), menstrual dysfunction (35%), infertility (24%), previous reproductive loss (22%), proliferative diseases of female reproductive organs (7%). 63% of patients had inflammatory diseases of respiratory tract, 33% – UTI, 20% – vaginal infections. Using of natural micronized progesterone allowed to significantly decrease the levels of IL-2, IL-6, TNF-α, and increase the level of IL-4, IL-10 which was not significantly different from those in the control group. The level of pro-inflammatory cytokines also decreases and anti-inflammatory also increases in patients that received traditional therapy, but their values remained significantly different from those in control group and group I. Conclusion: Chronic inflammation is launching an initial immune inflammatory response that is accompanied by insufficient secretion of endogenous progesterone and promotes the development of threatened preterm labour. Application 200 mg of sublingual form of micronized progesterone during 4 weeks provides rapid reduction of preterm labour symptoms which women with previous chronic infection had.