Vol. 7, Issue 7 (2018)

Author(s):
Nadiya Stasiuk

Abstract:
The purpose of study was to evaluate of dynamics of tumor necrosis factor –alfa (TNF-α) and soluble platelet-endothelial cell adhesion molecule -1 (sPECAM-1) in oral fluid of patients with generalized periodontitis with or without CHD during treatment. Material and Methods: 193 patients with generalized periodontitis were observed (63 without and 130 with chronic CHD – stable angina, FC II-III (CCS)). The levels of TNF-α and sPECAM-1 in gingival fluid were detected by ELISA method. Results: The level of TNF-α in gingival fluid of patients with stable angina was higher for 22.13% and for 32.29% in observed patients with generalized periodontitis I and II stage relatively (p<0.05). Its concentration was significant decreased after treatment in all groups, but more strong in patients with additional use of immunomodulators. In patients with angina pectoris normalization of TNF-α levels was more slowly compared group without coronary atherosclerosis. Similar results were obtained accordance of levels of sPECAM-1 in gingival fluids of observed patients. Conclusion: Additional prescription of immunomodulator Immuno-Ton and extratemporal gel with “Enterosgel” and herbal concentrate “Dzherelo” caused more significant normalizing of local inflammation activity in patients with generalized periodontitis.