Vol. 7, Issue 7 (2018)

Author(s):
Sumaiya Parveen and Sirisha Mittapally

Abstract:
Human fungal diseases pose a significant danger, but often overlooked, burden on public health, affecting over 1 billion people worldwide. Superficial fungal infections (e.g. nail, skin and urogenital) affect most people at some point in their lifetimes, but are usually curable when treated with antifungal drugs. Nevertheless, they affect quality of life and burden health services. Transdermal drug delivery is one of the promising drug delivery system for administration of drug across the skin but it has drawback of less permeability due to the stratum corneum, the outer most protective layer which prohibit the entry of xenobiotics. Therefore several vesicular drug delivery systems have been developed. The present aim of the study is to increase the permeability of Bifonazole which is a broad spectrum antifungal imidazole drug. It is a class iv drug which has less permeability and low solubility, so as to increase the permeability and solubility, it has been loaded into one of the best vesicular system i.e. transferosomes which has ultradeformable flexibility. In this study 12 formulations were prepared by reverse phase evaporation method using soya lecithin, span60, span 80 and tween 80 and evaluated for in vitro drug release. Five formulations for each surfactant were prepared by keeping the drug concentration constant. Among three surfactants span 60 showed better results. Among the five formulations of span 60, F1 and F2 with ratio of 2:1 and 4:1 of soya lecithin and span 60 respectively showed highest drug release of 75.905% and 94.8% respectively. F2 showed highest drug content and entrapment efficiency of 91.25 and 93.13%.But zeta potential report showed very low stability; hence to increase the stability of formulation; cholesterol was added in the ratio of 2:1 and 4:1 of phospholipid and cholesterol respectively. Then the zeta potential results of formulation were in the acceptable range. Hence it can be concluded that Bifonazole can be loaded in to transferosomal carrier which was found to be effective for increasing the permeability and can be proceeded for further future studies.