Vol. 7, Issue 7 (2018)

Author(s):
Shadma Chisti, DCP Singh, Swati Gupta and Mohd Asif Khan

Abstract:
Medicinal Chemistry concerns the discovery, the development, the identification and the interpretation of the mode of action of biologically active compounds at the molecular level. Some other survey of literature reveals that no sufficient work regarding synthesis and biological evaluation of some novel pyrazoline derivatives have been reported. So the present study was designed to synthesis and evaluates the biological potential of some novel pyrazoline derivatives. Pyrazoline derivatives were chemically synthesized, crystallized and identified and characterized by melting point determination, Thin Layer Chromatography (TLC), Infrared (IR) and Nuclear Magnetic Resonance (NMR) techniques. The albino rats of either sex weighing 180-250 g were used for the study. Animals were procured from the animal housing facility of SPS, IFTM University Moradabad (Reg. no. 837/ac/04/CPCSEA). In screening of anti-inflammatory effect, Indomethacin was used as standard drug against carrageenan induced rat paw edema by mercury displacement method (Plethysmometer). Zone of inhibition technique was used for evaluation of anti-bacterial potential against Gram +ve= Bacillus subtilis, Staphylococcus aureus and Gram –ve= E.coli, Pseudomonas Aeruginosa; ciprofloxacin was kept as standard. In results, both tests exhibited significant level of anti-inflammatory and antibacterial activity comparable to standard. In conclusion, the present study reveals that some pyrazoline derivatives could be used as a template for the future development through modification or derivatization to design more potent therapeutic agents.