Vol. 7, Issue 7 (2018)

Author(s):
Dr. Anand Mishra, Dr Rakesh Gupta, Dr Amit Kumar Nayak, Dr. Kapil Kumar Malviya, Dr. Sashikant Pandey, Dr. Surendra Kumar Pandey and Dr. Sashikant Verma

Abstract:
Introduction: Zidovidine (ZDV) and Efavirenz (EFZ) are anti HIV drugs widely used as combination chemotherapy to prevent maternal to child transmission. However the safety profile of these drugs has not been tested. Materials and Method: MDA and Reduced Glutathione wer tested in brain of the fetal mice after they wer dissected out in control and other 3 treated groups given ZDV, EFZ and ZDV+ EFZ in dose of 50mg/kg. Results: There is increased level of MDA and decreased levels of reduced glutathione in treated group as compared to the control and the maximum variation was seen in combination group. Conclusion: Zidovudine and Efavirenz leaded to increased oxidative stress injury in brain of fetal mice and thus can lead to neurodegeneration.