Vol. 12, Issue 11 (2023)

Author(s):
Ambrush Shanker, Tisu Tayeng, Shivani Dobhal, M Bishwapati Devi, Siddhartha Singh and Bikram Singh

Abstract:
The multifaceted pharmacological potential of Zanthoxylum rhetsa is increasingly recognized in the scientific community. This article elucidates the profound antioxidant, antibacterial, anti-inflammatory, and anticancer properties of Z. rhetsa, presenting a strong case for its application in therapeutics. The antioxidant capacity of Z. rhetsa seed oil is showcased through studies employing the DPPH assay, with results comparable to that of established antioxidants like α-tocopherol. Moreover, extracts from different parts of the plant have demonstrated superior antioxidant activities when juxtaposed with synthetic antioxidants such as BHT and PG. The exploration of its antibacterial effects reveals efficacy against various pathogenic bacteria, highlighting its potential to combat antibiotic resistance. The anti-inflammatory properties of Z. rhetsa are also well-documented, with evidence of significant inhibition of inflammatory mediators in macrophages. Furthermore, its anticancer effects have been observed across various cell lines, with components such as flavonoids and limonoids playing a critical role in inducing apoptosis and inhibiting angiogenesis. These promising in vitro results support the potential of Z. rhetsa as a natural source for the development of new pharmaceutical agents. However, the translation of these findings into clinical practice necessitates further research on the bioactive compounds' mechanisms of action, safety, and efficacy in human models. The current article synthesizes these various strands of research, accentuating the importance of Z. rhetsa in the development of future therapeutic agents.