Vol. 7, Issue 8 (2018)

Author(s):
Dinesh, RS Bisla, Rishi Tayal, RN Chaudhary and Ashok Kumar

Abstract:
The objective of present study was to evaluate anaesthetic efficacy and safety of anaesthetic combinations of atropine-midazolam-pentazocine-propofol-isoflurane and atropine-midazolam-pentazocine-ketamine-isoflurane in female dogs undergoing mammary tumor resection. The study was carried out in 10 female dogs undergoing mammary tumor resection which, were divided in to two groups. In both the groups C-I and C-II, premedication was done with atropine-midazolam-pentazocine @0.04mg/kg, 0.5mg/kg and 1mg/kg body weight respectively. In group C-I, 1% propofol (IV, to effect) was used for induction. Whereas, in group C-II ketamine-midazolam combination (@ 5mg/kg and 0.20 mg/kg respectively IV) was used for induction. Maintenance was done with isoflurane in 100% oxygen in both the groups. Effect on quality of anaesthesia, behavioural changes, physiological changes, haematological changes and changes in blood biochemical parameters were observed till 24 hours after recovery from anaesthesia. No significant difference was observed between two groups in different parameters at various time intervals during observation. However, induction was found to be more rapid and smooth in group C-I as compared to C-II.