Vol. 7, Issue 8 (2018)

Author(s):
Om Prakash, S Gomathinayagam, P Azhahianambi, ST Bino Sundar, Namita Shulka and Ajeet Kumar Pandey

Abstract:
The commercial drug, Nakku Poochi Kolli Kudineer (NPK) chooranum, contains extract of several herbs i.e. Butea monosperma, Nigella sativa, Embelia ribes, Trachyspermum ammi, Operculina turpethum, Cassia augustifolia and Picrorhiza kurroa and used for removal of round worms in human beings. An in vitro study with H. contortus was carried out to see the anthelmintic effect of this drug egg hatching and larval paralysis using NPK as concentration of 1, 3, 5, 10, 20, 30, 40, 50, 70 and 100 %. Contraction of uterus with drug, number of expelled eggs by female worm had significantly (P<0.05) increased and expelling egg was dose dependent. Egg hatch was not affected and complete paralysis of worm was observed in 100% concentration of NPK at the end of 8 hours. Paralysis effect was also dose dependent. This study has proved that NPK has the ability to increase uterine contraction of female H. contortus thus, resulting in expulsion of numerous numbers of eggs than normal. This effect could be used in harvesting more eggs in quicker time for using Egg hatch assay.Further, NPK has also moderate paralytic activity of H. contortus.