Vol. 7, Issue 8 (2018)

Author(s):
Prasanta Kumar Koustasa Mishra and Indhu MS

Abstract:
The complement mediated lysis is one of the few combating responses from host defence system. It acts coherently with innate and adaptive immune system. The complement system contains many glycoproteins which are normally present in inactive state. Upon activation, they initiate cascade of reactions leading to formation of a cytolytic complex otherwise known as membrane attack complex (MAC). C9 is the terminal component of such complexes. More than about 15, C9 molecules aggregates in this process. Goats are considered as hardy animals, resistant to various diseases. Very few literatures are there describing the goat immune system components. In the present study, an attempt was made to amplify the C9 coding sequence of goat which came to be around 2 kb. A phylogenetic analysis of the C9 sequence was also done to examine the distribution pattern across other ruminants and carnivores