Vol. 12, Issue 12 (2023)

Author(s):
Modepalli Poojitha, Chinnabala Ramesh, KN Lakshmi Shivani, JS Rudra Bhavani, Banoth Bhargav Naik, P Roshan Ali, Dr. V Venkata Rajesham and T Ramarao

Abstract:
Diabetes mellitus (DM) is a metabolic disease that is widespread around the world. Its frightening rate of occurrence places a heavy load on medical professionals. Diabetes is a chronic disease which is mainly caused by the decreased production of insulin. DM leads to various complications because of high severity of Hypertension, which leads to mortality and morbidity. Macro-vascular complications of diabetes, includes coronary heart disease, stroke and peripheral vascular disease. Micro-vascular complications include End-stage renal disease (ESRD or Nephropathy), retinopathy and neuropathy. Flavonoids are phenolic chemicals found in fungus, fruits, and vegetables as secondary metabolites. Flavonoids are further classified into 6 sub classes: flavonols, flavones, flavanones, isoflavones, flavanols, and anthocyanidins. Curcumin, quercetin, and rutin are Flavonoids with high antioxidant potential that are used to treat a broad spectrum of diabetic ailments. Flavonoids isolated from nature have anti-diabetic properties. Flavonoids, also improve diabetes pathogenesis and complications by regulating glucose metabolism, hepatic enzyme activity, and lipid profile. Quercetin has been clinically shown to help patients with diabetic retinopathy. The natural product kaempferol has potent anti- diabetic effects. Naringenin is a plant-based product used to treat diabetes and other metabolic diseases. The majority of research shows that some dietary flavonoids have a beneficial effect on diabetes. This review aims to shed light on the possible roles of flavonoids in avoiding or alleviating problems associated with diabetes.