Vol. 7, Issue 8 (2018)

Author(s):
Rafiq Ahmad Shah, DM Makhdoomi, Md Moin Ansari, Sheikh Tajamul Islam, Bilal Ahmad Gojri, Abdul Shakoor Bhat and Mehraj u din Naikoo

Abstract:
The powerful anti-inflammatory as well as analgesic property of steroids through inhibition of phospholipids A₂ and by blocking transmission in nociceptive C-fibers but not in myelinated A-beta fibers have been well documented in the literature. We tried to investigate the effect of isoflupredone acetate as an adjuvant to 2% xylocaine hydrochloride. Twenty four young cow calves were divided randomly in 4 groups A, B, C and D. In group A, 20 ml of 2% Xylocaine hydrochloride was injected as in a traditional manner without under ultrasound guidance. In group B, the total dose of local anaesthetic was decreased and the calves were injected 18ml of 2% xylocaine hydrochloride mixed with 2ml (4mg) isoflupredone acetate. In groups C and D, brachial plexus nerve block was performed under the guidance of ultrasound scanner by using 20ml of 2% xylocaine hydrochloride and 18ml of 2% xylocaine hydrochloride mixed with 2ml (4mg) isoflupredone acetate respectively. The onset and duration of sensory/motor blockade parameters were observed at time interval 5, 10, 15, 20, 30, 45, 60, 75, 90, 120, 135, 150, 165 and 180 min after local anesthetic injection. The decrease in the total dose of local anesthetic did not significantly decrease the onset and duration of anesthesia indicating analgesic effect of isoflupredone. Hence isoflupredone acetate can be used as an adjuvant to local anesthetic for prolonging the duration of anesthesia.