Vol. 7, Issue 8 (2018)

Objectives: The main objective of the study is to assess the prescription pattern of antibiotics and resistance pattern of antibiotics towards organisms and drug interactions.

Methods: Patients who met the study criteria were included in the study. 255 prescriptions were examined in the inpatient department of tertiary care hospital from the departments of General Medicine, Cardiology, Nephrology, Gastroenterology, Neurology, Oncology, orthopaedics and Pulmonology. The required data like patient demographics, medication charts, culture sensitivity reports etc were recorded in the designed data collection forms and the data was analyzed to determine prescribing and resistance pattern of antibiotics.

Results: In our study male patients were more infected with bacteria than females. Polypharmacy was more commonly seen. Most of the antibiotics were administered through intravenous route. Beta-lactam and Beta-lactamase inhibitor combinations (25.6%) were frequently prescribed and among them mostly Cefoperazone + Sulbactam (62.9%) was the drug of choice. Among single antibiotics Carbapenems (13.9%) were prescribed widely. Cefipime and Trimethoprim/Sulfamethoxazole (91) showed more resistance towards the isolated organisms. Meropenem (101) was more susceptible towards the isolated organisms. Serious interactions; moderate interactions; minor interactions with antibiotics were observed.

Conclusion: Rational prescribing of antibiotics is required in order to prevent the resistance of antibiotics and Polypharmacy. Physicians should consider the culture sensitivity reports before prescribing the antibiotics and should have an idea about interactions of antibiotics with other drugs while prescribing. Create awareness of antibiotics usage in the population to avoid emerging resistance of antibiotics.