Vol. 13, Issue 2 (2024)

Author(s):
Shweta Chand Thakuri, Mohit Panwar, Vijay Kumar Juyal, Rashmi and Viveka Nand

Abstract:
Phenylpyrimidine derivatives are a subclass of pyrimidine derivatives that have been extensively studied for their herbicidal activity. These compounds contain a phenyl group attached to the pyrimidine ring. The herbicidal activity of phenylpyrimidine derivatives is a result of their ability to inhibit specific enzymes involved in plant growth and development, leading to growth inhibition and death of the weed. A series of highly functionalized pyrimidine derivatives were synthesized. All of these compounds were confirmed by ¹H NMR, ¹³C NMR, elemental, FT-IR, and mass spectrum analysis. Their herbicidal activities were screened in vitro against the sterilized seeds of Raphanus sativus at different concentrations. The compounds showed noticeable pre-emergent herbicidal activities. The herbicidal activity results of the phenylpyrimidine-5-carboxylate derivative were found to be better than its -chloro and -methoxy derivatives but were below par with standard pendimethalin. In silico studies were carried out to predict the toxicity and herbicide-likeness using PROTOX-II software and SwissADME predictor. The compounds fared well in both in vitro and in silico studies providing ample scope for further modifications and study of phenylpyrimidine-5-carboxylate derivatives as a potent herbicide.