Vol. 13, Issue 3 (2024)

The present study was taken up to evaluate the efficacy of Trigonella foenum graecum and Coccinia indica individualy and in combination along with glibenclamide in streptozotocin induced diabetic rats for a period of 90 days. The various groups in this study included normal control (Group-I), diabetic control (Group-II), diabetic rats treated with glibenclamide (Group-III), diabetic rats treated with Trigonella foenum graecum (Group-IV), diabetic rats treated with Coccinia indica (Group-V), diabetic rats treated with Trigonella foenum graecum and Coccinia indica (Group-VI), diabetic rats treated with Trigonella foenum graecum and glibenclamide (Group-VII), diabetic rats treated with Coccinia indica and glibenclamide (Group-VIII). Diabetic rats treated with Trigonella foenum graecum, Coccinia indica and glibenclamide (Group-IX) respectively. There was significant variation in Hematological and pathomorphological parameters of diabetic rats when compared to normal control rats. The alleviation of the diabetic and its complications induced by streptozotocin was observed in all the treatment groups with variable degree of improvement. Trigonella foenum graecum and Coccinia indica extracts were effective in alleviating streptozotocin induced diabetes and were comparable with glibenclamide. Combination of Trigonella foenum graecum with glibenclamide and Coccinia indica with glibenclamide showed better improvement in hematological parameters compared to individual extracts alone and improvement was statistically significant. However the combined treatment of Coccinia indica with glibenclamide half dose and Trigonella foenum graecum and Coccinia indica with glibenclamide half dose revealed a very good improvement in hematological parameters which indicated a synergistic effect between Coccinia indica and glibenclamide half dose.