Vol. 13, Issue 6 (2024)

Author(s):
Pavani Ch. SN, Venkata Ramana K, Reddy KCS, Kalyani P and Swathi B

Abstract:
Pyometra is the most prevalent and life-threatening disease condition in dogs. In the present study, an attempt was made to study haematological, biochemical and physiological parameters in bitches affected with Pyometra to come out with clinical status of bitch and predict the prognosis. Evaluation of various parameters was done before, during and at the end of treatment. Study has been carried out on twenty-four bitches of different age groups and breeds with open pyometra. Six reproductively sound bitches were considered as control group (Group I). Twenty-four pyometra affected bitches were randomly divided into four groups (n=6) namely II, III and IV treated with different protocols. Group II treated with Mifepristone @ 2.5 mg/kg body weight per oral route for 5 days. Group III treated with Mifepristone @ 2.5 mg/kg body weight per oral along with Misoprostol intravaginal route @ 100 mg, Group IV treated with Mifepristone @ 2.5 mg/kg body weight along with Cloprostenol sodium @ 25 μg/day along with normal saline intravaginal douching using catheter and, Group V treated with Mifepristone @ 2.5 mg/kg body weight once daily per oral for five days along with 2% N- Acetyl Cysteine intravaginal douching using catheter. Physiological parameters like temperature, respiratory rate and heart rate were nearly similar in control and pyometra affected bitches. There was significant difference observed in Total Leucocyte Count (TLC), Haemoglobin, packed cell volume and total erythrocyte count between control group and pyometra affected bitches. Anemia and leuckocytosis was observed in the affected bitches. In biochemical parameters alkaline phosphatase differed significantly in pyometra affected bitches than control group. Treatment response was confirmed by disappearance of clinical signs of pyometra, changes in physiological, haematological and biochemical parameters and later by ultrasonography. Results of the present clinical study revealed that combination protocol of Mifepristone with Misoprostol was found to be more advantageous followed by protocols using Mifepristone in combination with Cloprostenol and Mifepristone alone over Mifepristone with 2% N- Acetyl Cysteine.