Vol. 7, Issue 12 (2018)

Author(s):
Bhadarka Dixita H, Patel Urvesh D, Solanki Shivani L, Modi Chirag M, Patel Harshad B and Singh VK

Abstract:
The present experiment was carried out to investigate the amelioration of paracetamol induced oxidative alterations by poly-herbal extract mixture (PHEM at 100, 200 and 300 mg/kg, PO) and silymarin (10 mg/kg, PO) in rats. SOD activity in serum was higher in rats treated with paracetamol whereas it was slightly lower in rats treated with either silymarin or PHEM at 200 mg/kg. The activities of SOD in liver and kidney of rats treated with paracetamol were non-significantly higher which were found lower in rats treated with higher dose of PHEM. Blood catalase activity was found lowered in paracetamol treated rats and significantly higher in PHEM treated groups (200 and 300 mg/kg). Activity of catalase in liver of rats treated with paracetamol was highest which was almost double than the value found for rats treated with PHEM at higher dose. Catalase activity in kidney in rats under treatment was not significantly altered. Blood GSH level was not significantly altered in all groups under the study. The GSH level in liver of rats treated with PHEM (200 and 300 mg/kg) were higher than those values observed in other groups. In conclusion, administration of PHEM orally at higher doses for 21 days has shown ameliorating effect against mild oxidative alterations caused by paracetamol in rats.