Vol. 8, Issue 1 (2019)

Author(s):
Dr. Shaikh Siraj N, Siddiqi Hifzurrahman MD Athar, Dr. GJ Khan, Shahid Raza, Mohd. Aslam Ansari

Abstract:
Solid dispersion is a unique & most widely used approaches to enhance the solubility as well as dissolution rate especially BCS class II drugs. The main purpose of development of solid dispersion is improving oral absorption and oral bioavailability of poor water soluble drug by using natural gum. Solid dispersion is prepared by using solvent evaporation method, kneading method, melting method, and lyophilisation method etc. Natural polymer and its modified forms can be used as a best alternative for improving bioavailability of poor water soluble drug in solid dispersion. Most of natural polymer are hydrophilic and having high swelling capacity. Many natural polymers like cyclodextrin and carbohydrate are most extensively used as a carrier for enhancing the solubility and dissolution rate in solid dispersion. This review focus on various aspects of Solid dispersion and Solid dispersion of poor water soluble drug by using natural polymers.