Vol. 8, Issue 3 (2019)

Author(s):
Rajeshwar V and Vasudha Bakshi

Abstract:
The purpose of present study was to formulate the Fast Dissolving tablets of Diltiazem Hcl tablets to achieve faster disintegration in the oral cavity without water. To achieve this goal attempts were made to enhance dissolution rate along with faster disintegration using superdisintegrants like croscarmellose sodium, sodium starc, h glycolate and crospovidone. Diltiazem Hydrochloride is an anti-hypertensive agent was selected as the active pharmaceutical ingredient in the study. The fast dissolving tablets were prepared by direct compression method and evaluated for hardness, thickness, and friability of the tablets. The in vitro drug release studies were performed for different formulations and to optimize the best formulae based on the dissolution profiles. Fourier transform infrared spectroscopy studies revealed that there was no interaction between Diltiazem Hydrochloride and excipients.