Vol. 8, Issue 3 (2019)

Author(s):
Puppala Raman Kumar, Puvvada Chaitanya, Rachakonda Kalyani, Rangisetti Mahalakshmi Poojitha, Udaru Bhavani and Siddela Tirumala Rao

Abstract:
The present study is an attempt to enhance the dissolution profile, absorption efficiency and bioavailability of water insoluble drugs, such as curcumin. A novel “Powder Solution Technology” or Liquisolid Compact Technology involves absorption and adsorption efficiency, which makes use of liquid medications, admixed with suitable carriers, coating materials and formulated into a free flowing, dry looking, Non-adherent and compressible powder forms. Formulations have been achieved by changing the proportion of carrier and coating material. Higher dissolution rates were observed in all liquisolid formulations, when compared with a conventional tablets and Pure Drug Mixture. The crystalline state of drug is changed to amorphous state; this transition occurs because the drug is in solution form and results of FTIR, revealed presence of all characteristics peaks of curcumin in formulations which confirm no drug excipient interactions. The amorphous form exhibited improvement in dissolution rates as well as apparent solubility was obtained because of the solubilization of Curcumin.