Vol. 8, Issue 4 (2019)

Author(s):
Salvi Neelima and Choudhary Gajendra Pratap

Abstract:
There are many side effects associated with the synthetic drug molecules and in case of diabetes there is drug regimen which means more synthetic drug and more associated side effects. Current work is based on the extraction of leaves of Aegle marmelos plant which is of natural origin; this will help to get rid of side effects and after that the problem was dosing frequency which is again a drawback of diabetes treatment. We had selected the vesicular carrier system for the drug release modification. Characterization and performance evaluation of vesicular system loaded with herbal plant extract of the aegle marmelos leaves was done. Liposomal dispersion was formulated and evaluated for the vesicle size distribution, percentage drug entrapment and In vitro drug release profile along with the stability studies. In vivo tissue distribution studies on albino rats suggested the accumulation of formulations in the different organs. These results suggest that the liposomal dispersion are not only effective in rapid attainment of high drug concentration in body and also maintain the same over prolonged period of time.